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2. Testosterone Biosynthesis and Metabolism. Testosterone is an androgen, meaning that it is a 19-carbon steroidal derivative of cholesterol (Figure 1) []. Typical of steroid synthesis, cholesterol is first converted to pregnenolone within mitochondria by the side-chain cleavage enzyme (P450 scc). Subsequently, pregnenolone is converted to a variety of different androgens [e. g .

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